Oncotype DX Breast Cancer Test Explained

Dr. Harness explains how the Oncotype DX breast cancer test is performed, how the score is determined and what the score means for newly diagnosed breast cancer patients.

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Dr. Jay K. Harness, MD, FACS: RNA, part of the makeup of your cells, is extracted from the tumor sample and then analyzed to determine the level of activity or expression of each of 21 genes.

The results of the analysis are then put into a mathematical equation to convert those measures into the current score result (a number between 0 and 100). The results correspond to the likelihood of breast cancer returning elsewhere in the body within the next ten years after the initial diagnosis of breast cancer, and the benefit that a woman may receive from undergoing chemotherapy, in addition to anti-hormonal therapy.

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Dr. Jay K. Harness is a board certified surgeon currently treating patients at St. Joesph Hospital in Orange, CA. Dr. Harness specializes in complete breast health, breast cancer surgery, oncoplastic reconstruction, genetic screening, management of breast health issues, risk assessment and counseling. Dr. Harness is the medical director for Breast Cancer Answers.com, and guides this first ever social media show’s information by drawing on his former leadership experience as the President of the American Society of Breast Surgeons and Breast Surgery International. Dr. Harness graduated from the University of Michigan, Ann Arbor in 1969 and spent time early on in his career at the University of Michigan Medical Center.


This information should not be relied upon as a substitute for personal medical advice, diagnosis or treatment. Use the information provided on this site solely at your own risk. If you have any concerns about your health, please consult with a physician.